The more differentiated a tumor is, the better the prognosis.” “The prognosis of how cancer cells will respond to treatment often relates to its status of differentiation. “In most cancers, cells are going through this rampant proliferation because cell-cycle regulators are not functioning properly,” she said. The findings are relevant to understanding normal development and also may be useful in cancer research, said University of Illinois Urbana-Champaign cell and developmental biology professor and department head Supriya Prasanth, who led the research. Once they differentiate, they usually stop actively proliferating. Only when BEND3 is downregulated can cells adopt their final form and function.
They discovered that a molecule known as BEND3 shuts down expression of hundreds of genes associated with differentiation, maintaining the cell’s stem cell-like status. In a study published in the Proceedings of the National Academy of Sciences, researchers report that they have identified a key regulator of this process. Scientists have long sought to understand the signals that prompt stem cells to switch off pluripotency and adopt their final functional state. Brian StaufferĮmbryonic stem cells and other pluripotent cells divide rapidly and have the capacity to become nearly any cell type in the body. The research team included, from left, undergraduate student Darya Asoudegi graduate students Neha Chetlangia and Fredy Kurniawan and Supriya Prasanth, a professor of cell and developmental biology at the U.
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